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What's the significant benefits from Benzocaine hydrochloride?

Views: 0     Author: Site Editor     Publish Time: 2022-04-18      Origin: Site

Benzocaine hydrochloride is used for cosmetic UV absorption, local anesthetics, pain relief for wounds, ulcers and hemorrhoids.

l What does benzocaine hydrochloride look like?

l Whats th application of benzocaine?

l What are the chemical data for benzocaine hydrochloride?

What does benzocaine hydrochloride look like?

White crysta: powder

Content: 99-101%

Melting point: greater than 208 degrees

Standard: USP26

Loss on drying: ≤0.5%

Ignition residue: ≤0.1%

Heavy metal:≤10ppm

Whats th application of benzocaine?

1. Properties of Aromatic First Amines

1) Weakly alkaline

2) Easy to oxidative deterioration

Application: It is necessary to take anti-oxidation measures when preparing its liquid, such as adjusting the pH to 3.5 to 5.5, and strictly control the sterilization temperature and time, and it is appropriate to sterilize it by circulating steam at 100 °C for 30 minutes.

3) Diazo coupling reaction

Application: Identification. In dilute hydrochloric acid, it forms a diazonium salt with sodium nitrite, and a coupling reaction occurs with basic β-naphthol to form a red azo compound.

4) Condensation reaction with p-aromatic aldehyde

Application: Identification. Under the condition of hydrochloric acid, it can condense with p-dimethylaminobenzaldehyde to generate yellow Schiff base.

5) Application: Examination of procaine hydrochloride p-aminobenzoic acid impurities by thin-layer method.

2. The nature of the ester bond

Easy hydrolysis failure.

Application: It is necessary to take anti-oxidation measures when preparing its liquid, such as adjusting the pH to 3.5 to 5.5, and strictly control the sterilization temperature and time, and it is appropriate to sterilize it by circulating steam at 100 °C for 30 minutes.

Application: should be shaded, sealed and stored.

Application: Identification. Its aqueous solution is added with sodium hydroxide solution, then a white precipitate of procaine is precipitated, and the ester is hydrolyzed by heating to produce diethylaminoethanol (steam turns red litmus paper blue) and sodium p-aminobenzoate, let it cool, add hydrochloric acid to acidify, namely A white precipitate of p-aminobenzoic acid is precipitated, which can be dissolved in an appropriate amount of hydrochloric acid.

What are the chemical data for benzocaine hydrochloride do you want to know?

Hydrophobic parameter calculation reference value (XlogP): 1.9

Number of hydrogen bond donors: 1

Number of hydrogen bond acceptors: 3

Number of rotatable chemical bonds: 3

Number of tautomers: 2

Topological Molecular Polar Surface Area (TPSA): 52.3

Number of heavy atoms: 12

Surface charge: 0

Complexity: 151

Number of isotope atoms: 0

Determine the number of atomic stereocenters: 0

Uncertain number of atomic stereocenters: 0

Determine the number of bond stereocenters: 0

Uncertain number of bond stereocenters: 0

Number of covalent bond units: 1

Molar Refractive Index: 46.89

Molar volume (cm3/mol): 146.1

Isotonic specific volume (90.2K): 377.7

Surface tension (dyne/cm): 44.6

Polarizability (10-24cm3): 18.59

Mulei (Wuhan) New Material Technology Co. Ltd has focused on the development and production of benzocaine for several years. And it commits to provide perfect service for every customer from all over the world. For more information you want to know, you can connect the https://www.whmulei.com/.


Our company was founded in 2016 since then we have pioneered in the manufacturing and trading of organic intermediates, pharmaceutical intermediates, chemical solvents and agrochemical. For us, product quality and customer service are of the most importance. read more

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