Views: 0 Author: Site Editor Publish Time: 2022-11-19 Origin: Site
PMK methyl glycidate CAS: 28578-16-7 can be used as an organic synthesis intermediate and pharmaceutical intermediate. It is mainly used in laboratory R & D process and pharmaceutical and chemical production process. PMK methyl glycidate CAS: 28578-16-7 plays an irreplaceable role in daily production.
What role does PMK methyl glycidate CAS: 28578-16-7 play in synthesis?
How to synthesize PMK methyl glycidate CAS: 28578-16-7 with isosafrole?
What is the method of direct synthesis of PMK methyl glycidate CAS: 28578-16-7 from safrole?
Most of the synthetic routes of 3,4-methylenedioxymethamphetamine (MDMA) are composed of compounds containing 3,4-methylenedioxyphenyl ring, such as safrole, isosafrole, piperine aldehyde, methyl bromide cream and piperine methyl ketone (PMK), among which PMK is the most important. The precursor compound of MDMA can be synthesized in underground treatment plant. MDMA can be prepared by simple lukat method or reductive amination method.
Synthesis of isosafrole raw materials
Isosafrole is an isomer of safrole. Isosafrole was oxidized to piperazinyl methyl ketone in organic acid medium with isosafrole as raw material. According to the different reaction steps, it can be divided into direct synthesis and indirect synthesis.
Piperazinyl methyl ketone was prepared from isosafrole by direct oxidation of isosafrole with peroxycarboxylic acid in organic acid medium. The "one-step" process does not need sulfuric acid treatment, uses less acid, has the advantages of simple operation, safety and less environmental pollution. In the presence of organic acids, hydrogen peroxide first reacts to form peroxy acid, and then oxidizes olefins in the system to form epoxy compounds. Due to the presence of formic acid in the system, the epoxy compound reacts with formic acid to form trans diol monoformate, which is hydrolyzed to obtain trans diol. The trans diol is heated under acidic conditions and isomerized into ketone through enol intermediate.
The direct synthesis method adopts the improved Wacker method, that is, oxidizing ethylene to acetaldehyde with oxygen in air and water containing palladium tetrachloride catalyst. Under the action of Wacker catalyst, terminal olefins, inner olefins and high carbon cyclic olefins can also be transformed.
However, due to the spatial effect of olefin structure and the isomerization of palladium catalyzed reaction, the yield of the reaction product is much lower than that of ethylene oxidation product. In order to improve the catalytic effect of Wacker catalyst, we can start with the selection of appropriate cosolvent, oxidant and palladium complex. Others directly synthesize piperidine methyl ketone with safrole as raw material, methanol as solvent, benzoquinone as oxidant and palladium chloride as catalyst.
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