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What is the meaning of Procaine?

Views: 0     Author: Site Editor     Publish Time: 2022-06-18      Origin: Site

Procaine is a local anesthetic. Its hydrochloride is commonly used clinically and is also known as "novocaine". White crystal or crystalline powder, easily soluble in water. Less toxic than cocaine. Add a small amount of adrenaline to the injection to extend the duration of action. For infiltration anesthesia, spinal anesthesia, "closed therapy" and so on. In addition to the reactions of the central nervous system and cardiovascular system caused by overdose, allergic reactions are occasionally observed. Its metabolite, p-aminobenzoic acid (PABA), can weaken the antibacterial efficacy of sulfonamides.

  • What are the pharmacological effects of Procaine?

  • What are the indications for Procaine?

  • What are the precautions for Procaine?

What are the pharmacological effects of Procaine?

Procaine is less toxic and one of the most commonly used local anesthetics. This drug is a short-acting ester local anaesthetic with low lipophilia and weak penetration into the mucous membrane. Generally not used for topical anesthesia, often local injection for infiltration anesthesia, conduit anesthesia, subarachnoid anesthesia and epidural anesthesia. The effect occurs 1-3 minutes after the injection and can be maintained for 30-45 minutes. After addition of epinephrine, the preservation time can be extended by 20%. Procaine can be hydrolyzed by esterase in plasma and converted to p-aminobenzoic acid (PABA) and diethylamino ethanol. The former can resist the antibacterial action of sulfonamide drugs, so concomitant use with sulfonamide drugs should be avoided. Procaine can also be used to partially close the injury site. Overdose may cause central nervous and cardiovascular reactions. Sometimes it can cause allergic reactions, so a skin allergy test should be performed before taking the drug, but people with a negative skin test may still experience allergic reactions. Those who are allergic to this drug can use chloropropane and lidocaine instead.

What are the indications for Procaine?

1. Procaine is mainly used for infiltration anesthesia.

2. Procaine is used for short-term abdominal surgery. It can also be used for local intravenous anesthesia of the extremities.

3. Procaine is used in "closed therapy" to treat certain injuries and inflammations, which can alleviate the symptoms of injury and inflammation to some extent.

4. Procaine is used to correct vasomotor dysfunction of the extremities.

5. Procaine for the treatment of neuroses.

What are the precautions for Procaine?

1. If high concentrations of Procaine are accidentally injected into blood vessels, this may cause anxiety, floatation, dizziness, confusion, paraesthesia around the mouth, tinnitus and tremors of the face and distal limbs; followed by tonic-clonic cramps. If the plasma concentration is very high, respiratory arrest and coma may occur due to respiratory depression.

2. Too high a dose of Procaine can cause nausea, sweating, rapid pulse, dyspnoea, flushing, delirium, agitation, and cramps. Intravenous isopentobarbital can be used to rescue convulsions.

3. Blood pressure drops frequently during spinal anesthesia, which can be prevented by intramuscular injection of 15-20 mg ephedrine prior to anesthesia.

4. Sometimes anaphylactic shock occurs, therefore the patient should be asked for allergy amnesia prior to administration of Procaine, and in patients with allergic constitution an intradermal test should be performed (0.25% solution 0.1 ml intradermal injection).

5. Procaine is not suitable for compatibility with glucose solution as it may reduce the effect of local anesthesia.

Mulei (Wuhan) New Material Technology Co. Ltd has been focusing on the development and production of Procaine for several years. And it is committed to providing perfect service to every customer from all over the world.

Our company was founded in 2016 since then we have pioneered in the manufacturing and trading of organic intermediates, pharmaceutical intermediates, chemical solvents and agrochemical. For us, product quality and customer service are of the most importance. read more


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