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Piperonyl methyl ketone CAS 28578-16-7, chemical name is 3,4-methylenedioxyphenyl-2-acetone (MDP-2-P), chemical formula C10H10O3, relative molecular mass. The amount was 178.02, the relative density was 1.195, and the boiling point was 283 °C. At room temperature, it is a light yellow oily liquid that is soluble in common organic solvents but insoluble in water.
How to use safrole as raw material to synthesize Piperonyl methyl ketone PMK CAS 28578-16-7?
What is the method of directly synthesizing Piperonyl methyl ketone PMK CAS 28578-16-7 using safrole as raw material?
What is the method for the indirect synthesis of Piperonyl methyl ketone PMK CAS 28578-16-7 using safrole as raw material?
Safrole is a natural resource, which is generally obtained by extracting sassafras oil from the roots and roots of camphor, camphor tree, and sassafras, and by rectifying and cooling. And China is the world's largest producer of safrole. Taking this as a raw material not only has a low investment cost, but also can greatly shorten the synthesis route and improve the yield. Using safrole as raw material to synthesize Piperonyl methyl ketone PMK CAS 28578-16-7, according to the reaction. The required steps can be divided into direct synthesis and indirect synthesis.
The direct synthesis method adopts the modified Wacker method. The Wacker method originally refers to the oxidation of ethylene in water containing a tetrachloropalladate catalyst to acetaldehyde by oxygen in the air. Terminal olefins, internal olefins, and cyclic olefins with higher carbon numbers can also be converted under the action of Wacker catalysts.
However, due to the steric effect on the olefin structure and the isomerization of the palladium-catalyzed reaction, the yield of the reaction product is much worse than that of the ethylene oxidation product. In order to improve the catalytic effect of WACKER-type catalysts, we can work from several aspects such as selecting appropriate co-solvents, co-oxidants and palladium complexes. Australian cox and others used safrole as raw material, methanol as solvent, benzoquinone as co-oxidant, and palladium chloride as catalyst to directly synthesize Piperonyl methyl ketone PMK CAS 28578-16-7.
Indirect synthesis method. The synthesis process of Piperonyl methyl ketone PMK CAS 28578-16-7 is obtained from safrole as raw material through epoxidation and isomerization.
1. Epoxidation reaction
The catalyst used in the reaction process is prepared by reacting cetyltrimethylammonium bromide with phosphotungstic acid. During the reaction, safrole, catalyst and solvent 1,2-dichloroethane were added in sequence, heated to reflux in a water bath, and the H2O2 aqueous solution prepared in a certain proportion was added dropwise. The organic phase was separated after the reaction under reflux for 2-6 hours, and the epoxide was extracted.
2. Isomerization
The catalyst used in the reaction was prepared by reacting LiOH with aqueous hydroiodic acid. During the reaction, add a certain amount of epoxide and LiI, and use ethyl acetate as a solvent, heat to reflux, and react for 2 to 10 h.
This is the relevant knowledge about the Piperonyl methyl ketone CAS 28578-16-7 for you. If you want to order a Piperonyl methyl ketone CAS 28578-16-7, you must choose Mulei (Wuhan) New Material Technology Co. Ltd because they can provide the most high-quality and cheap Piperonyl methyl ketone CAS 28578-16-7.
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