What is the importance of Levamisole hydrochloride?

Levamisole hydrochloride is an insect repellant and immunomodulator. It can regulate immune function and mainly acts on T lymphocytes to induce the early differentiation and maturation of T cells into functional T cells, thereby promoting the normal HT function of T cells, and can also strengthen the phagocytosis and chemotaxis of macrophages. Improve the activity of natural killer cells, produce endogenous interferon, improve immune function to make it normal, effectively prevent the progression of pneumonia, and improve symptoms such as cough and lung sounds.

• What is the pharmacology and toxicology of Levamisole hydrochloride?

• What do you know about Levamisol Hcl?

• How is Levamisole hydrochloride formulated?

What is the pharmacology and toxicology of Levamisole hydrochloride?

 Levamisole hydrochloride is the levorotatory form of tetraimidazole, which can selectively inhibit succinate dehydrogenase in worm muscles, so that fumaric acid cannot be reduced to succinate, thereby affecting the anaerobic metabolism of worm muscles and reducing energy production. When the worm is in contact with it, it can depolarize the neuromuscular, and the muscle will continue to contract and cause paralysis; the cholinergic effect of the drug is beneficial to the excretion of the worm. Its activity is about 1~2 times that of tetraimidazole (racemate), and the toxic and side effects are low. Drugs may have inhibitory effects on the microtubule structure of parasites. Levamisole also has immunomodulatory and immunostimulatory functions.

What do you know about Levamisol Hcl?

Levamisol Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. A number of these complications have been reported in cocaine users with the increasing use of levamisol as a falsifying agent. Levamisol reversibly and non-competitively inhibits most alkaline phosphatase isoforms (e.g., human liver, bone, kidney, and spleen), with the exception of intestinal and placental isoforms. It is therefore used together with a substrate as an inhibitor to reduce alkaline phosphatase background activity in biomedical assays that include detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or western blot protocols. It is used to immobilize the nematode C. elegans on slides for imaging.

How is Levamisole hydrochloride formulated?

1. Sodium hydroxide titrant (0.1mol/L)

Preparation: Take 5.6mL of clear saturated sodium hydroxide solution, add freshly boiled cold water to make 1000mL.

Calibration: Take about 0.6 g of the benchmark potassium hydrogen phthalate dried to constant weight at 105 °C, accurately weigh, add 50 mL of freshly boiled cold water, shake to dissolve as much as possible; add 2 drops of phenolphthalein indicator solution, use In this titration, when approaching the end point, potassium hydrogen phthalate should be completely dissolved, and the solution should be titrated to a pink color. Each 1mL of sodium hydroxide titration solution (1mol/L) is equivalent to 20.42mg of potassium hydrogen phthalate. Calculate the concentration of this solution according to the consumption of this solution and the amount of potassium hydrogen phthalate taken.

Storage: Put it in a polyethylene plastic bottle and keep it sealed; there are 2 holes in the stopper, and a glass tube is inserted into each hole.

2. Phenolphthalein indicator solution

Take 1 g of phenolphthalein, add 100 mL of ethanol to dissolve.

Steps:

Precisely weigh about 0.2 g of the test sample, put it in a conical flask, add 20 mL of ethanol to dissolve it, titrate with sodium hydroxide titration solution (0.1 mol/L) according to the potentiometric titration method, and correct the titration result with a blank test. Record the volume (mL) of the sodium hydroxide titration solution consumed, and each 1 mL of the sodium hydroxide titration solution (0.1 mol/L) is equivalent to 24.08 mg of C11H12N2S ·HCl.

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