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What is the function of phenacetin?

Views: 0     Author: Site Editor     Publish Time: 2022-04-20      Origin: Site

The antipyretic effect of phenacetin is stronger than the analgesic effect. The potency of the drug is comparable to that of aspirin, the effect is slow and long-lasting, and the toxicity is low.

  • What role does phenacetin play?

  • What properties does phenacetin have?

  • How is phenacetin made?

What role does phenacetin play?

Both phenacetin and its metabolite paracetamol have a fever-lowering effect. Since phenacetin cannot be converted to paracetamol with enzyme inhibitors, it can nevertheless show a significant fever-lowering effect. Therefore, the fever-lowering effect after thread administration is not only caused by the active ingredient paracetamol. The mild analgesic effect of phenacetin can generally be maintained for 3-4 hours; The synergistic effect of phenacetin in combination with salicylic acid enhances the analgesic effect. Clinically, it is mainly used as an antipyretic and analgesic in small animals. This product is also one of the components of APC tablets.

What is the properties of phenacetin?

Phenacetin is a fever-lowering and pain-relieving active ingredient with the sum formula C10H13NO2. It is white, with sparkling scaly crystals or white crystalline powder, odorless and slightly bitter in taste. Soluble in ethanol or chloroform, easily soluble in boiling water, very easily soluble in water.

Phenacetin is nitrided with concentrated nitric acid/acetic anhydride and recrystallized with water to obtain golden yellow 2-nitro-4-ethoxyacetanilide.

Phenacetin is easily absorbed when taken orally and its effect begins 20-30 minutes after taking it. After 5-6 hours after absorption, the majority of phenacetin in the liver is rapidly deethylated to form acetaminophen (paracetamol), which has antipyretic and analgesic effects. Subsequently, it is excreted mainly in the form of binding to the urine; a small part is deacetylated to produce p-aminophenethyl ether, which converts hemoglobin into methemoglobin and thus shows the cyanotic toxicity of phenacetin.

How is phenacetin made?

It is obtained by the action of acetamidophenol and sodium methylate: first add p-acetamidophenol to sodium methyl, then slowly add iodethane, heat 1 h under reflux, cool and filter, dissolve the obtained raw product into ethanol, filter and dilute the filtrate with hot water, then cool, filter and dry to get the finished product, and the yield is 80% of the theoretical quantity. The first method may also use acetic acid instead of benzene as a solvent, and the method is as follows. Heat 40% diluted acetic acid to boil, fill p-aminophenethyl ether, evaporate water, add ice vinegar when temperature rises to 150 °C, 1 h under reflux, continue steaming when temperature rises above 150° C, take sample to measure free aminobenzene diethyl ether, add acetic anhydride according to the amount of remaining aminophenethyl ether, Return flow reaction for 0.5h, test endpoint, decompress after passing qualification, recover acetic acid until the amino content is reached below 0.046 and the acidity below 0.2%, the reaction liquid is poured into the hot refining mother liquor, stirred to cool to 40 °C, filtered to obtain raw phenacetin. Refining, adding boiling water or refining mother liquor to raw phenacetin, heating and stirring for dissolving, filtering, adjusting the filtrate to pH4.5–4.7 with acid, adding activated carbon and sodium thiosulfate, stirring and decolouring, filtering, cooling and crystallizing the filtrate, filtration and airflow Dry phenacetin.

This is all about phenacetin! If you want more information about phenacetin, please contact Mulei (Wuhan) New Material Technology Co. Ltd.

Our company was founded in 2016 since then we have pioneered in the manufacturing and trading of organic intermediates, pharmaceutical intermediates, chemical solvents and agrochemical. For us, product quality and customer service are of the most importance. read more


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