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Phenacetin is a member of the class of acetamides, in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. Phenacetin play the role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase inhibitor. Phenacetin is a member of acetamides and an aromatic ether, which derives from a N-phenylacetamide, a 4-ethoxyaniline and a paracetamol.
What is the function of amide compound of Phenacetin?
How to test Phenacetin?
How to do if there is any adverse reaction when using Phenacetin?
Amide compound of Phenacetin is an aniline antipyretic and analgesic drug. Acetaminophen is a metabolite of Phenacetin in the body, which is one type of amide compound. The antipyretic and analgesic effect of amide compound is similar to that of Aspirin.
The anti-inflammatory and anti-rheumatic effects of amide compound of Phenacetin are very weak or even, have no curative effect. Amide compound of Phenacetin has no irritation to the gastrointestinal tract, as well as not causing coagulation disorders.
Amide compound of Phenacetin has a similar antidiuretic effect, which can promote the reabsorption of water so that Phenacetin has a certain effect on diabetes insipidus.
Amide compound of Phenacetin has antipyretic and analgesic effects without anti-inflammatory and anti-rheumatic effects. Acetaminophen is mainly metabolized in the liver, while a small part is deacetylated to form p-aminophenethyl ether. After being further metabolized to iminoquinone, hemoglobin can be oxidized to methemoglobin. When the amount of Phenacetin is large, cyanosis or even severe hypoxia can occur, especially for children. Long-term or excessive use of Phenacetin can cause hemolytic anemia, liver and kidney damage. Due to the high toxicity of Phenacetin, it has been replaced by paracetamol and is now only used in certain compound preparations.
Take 0.1g of Phenacetin and add 5ml of hydrochloric acid. Then boil for about 2 minutes, add 10ml of water to cool and filter. Add 1 drop of potassium dichromate to the filtrate. Phenacetin will appear purple and become a ruby red immediately.
Take 0.6g of Phenacetin, put it in an Erlenmeyer flask. Then add 50mg of nickel-aluminum alloy, 5ml of 90% ethanol, 10ml of water and 2ml of sodium hydroxide solution. Place Phenacetin in a water bath, heat to reflux for 10 minutes to cool. Filter through a chloride-free filter paper into a 50ml measuring flask. Wash the conical flask and filter paper with water, and put them into the measuring flask, as well as adding water to dilute to the mark. Shake well and divide into 25ml. If turbidity occurs, compare it with the 25ml blank solution treated by the above method, adding 6ml standard sodium chloride.
Phenacetin is forbidden for those allergic to phenacetin. Phenacetin is forbidden for patients with liver and kidney dysfunction. Phenacetin is forbidden for patients with a history of hemolytic disease or other blood diseases. Phenacetin is forbidden for pregnant women.
The elderly and children should use Phenacetin with caution. Breastfeeding women should use Phenacetin with caution, if needed, women should suspend breastfeeding. Phenacetin is a prescription drug, which means the doctor must prescribe the medicine according to the condition. Patients must follow the doctor's order to take the medicine, including the usage, dosage, and time of administration. Do not self-administer drugs in accordance with the drug instructions without authorization.
There are adverse reactions to the Phenacetin. If the adverse reaction of Phenacetin is mild, the medication can be adhered to. If the adverse reaction of Phenacetin is severe, seek medical attention immediately.
The possible adverse reactions of Phenacetin include hemolytic anemia, methemoglobinemia, renal papillary necrosis, renal pelvic metastatic cell carcinoma, and liver necrosis.
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