What is the function of Procaine hydrochloride?

Procaine hydrochloride is a drug. Procaine hydrochloride acts on peripheral nerves to produce conduction block. It penetrates the nerve cell membrane in a diffuse manner depending on the concentration gradient, blocks sodium ion channels on the inside, and increases the excitation threshold of nerve cells. With loss of excitability and conductivity, information transmission is blocked, with good local anesthesia.

• What are the physicochemical properties of Procaine hydrochloride?

• How is Procaine hydrochloride used?

• What are the chemical properties of Procaine hydrochloride?

What are the physicochemical properties of Procaine hydrochloride?

The appearance of Procaine hydrochloride is white crystals or crystalline powder, odorless, slightly bitter in taste, followed by numbness. Melting point 155-156°C, boiling point 195-196°C/17mm, flash point 195-196°C/17mm, Solubility: This product is easily soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, insoluble in ether.

The ester bond of Procaine hydrochloride is easily hydrolyzed, and temperature and pH affect the rate of hydrolysis. Aromatic primary amine groups are prone to oxidation and discoloration. When preparing injections, the pH should be adjusted to 3.5-5.0, and the sterilization temperature and time should be controlled. Steam sterilization at 100 °C for 30 minutes is appropriate. Ampere is filled with inert gas, and antioxidants are added to remove metal ions or Add metal ion masking agent, keep away from light, airtight, and place in a cool place. Aromatic primary amino group can undergo diazotization-coupling reaction, that is, after reacting with sodium nitrite in dilute hydrochloric acid, adding basic β-naphthol test solution 5 to produce orange (scarlet) red azo compound precipitate.

How is Procaine hydrochloride used?

Proca hydrochloride acts on peripheral nerves to produce conduction block, penetrates the nerve cell membrane in a diffuse manner depending on the concentration gradient, blocks sodium ion channels on the inside, increases the excitation threshold of nerve cells, loses excitability and conductivity, and transmits information. is blocked and has a good local anesthetic effect.

Procaine hydrochloride is used for infiltration anesthesia. The concentration of the solution is mostly 0.25% to 0.5%. For spinal anesthesia, the amount should not exceed 0.15g at a time, and a 5% solution should be used. For local intravenous anesthesia of the limbs, 0.5% solution 40 ~ 150ml. Nerve conduction block with 1% to 2% solution, 1 time no more than 1g.

What are the chemical properties of Procaine hydrochloride?

Chemical properties of Procaine hydrochloride:

1. Aromatic primary amine group characteristics, can show diazotization-coupling reaction, condensation reaction with aromatic aldehyde, easy to oxidize and change color, etc.

2. The ester bond is easily hydrolyzed. The hydrolysis product is mainly p-aminobenzoic acid (PABA).

3. The free base is insoluble in water and weakly alkaline.

Chemical properties of acetaminophen:

1. The hydrolyzate has the characteristics of aromatic primary amino group. The drug structure has an amide group, which is easily hydrolyzed in an acidic solution to obtain a product with an aromatic primary amino group. Therefore, the hydrolyzate of the drug can have the characteristic reaction of aromatic primary amino groups.

2. The hydrolyzate is easy to be esterified. Acetaminophen is hydrolyzed to produce acetic acid, which can react with ethanol in a sulfuric acid medium to emit the aroma of ethyl acetate.

3. It has a color reaction with ferric chloride. Acetaminophen has a phenolic hydroxyl group and can react with ferric chloride to form color.

This is all about the Procaine hydrochloride. If you would like to receive more information about the Procaine hydrochloride, please connect Mulei (Wuhan) New Material Technology Co. Ltd, and they will be happy to answer your question!