Views: 0 Author: Site Editor Publish Time: 2022-11-22 Origin: Site
Methyl piperonyl glycidyl ethyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process. In the daily production process, piperonyl methyl ketone CAS 28578-16-7 PMK powder has an irreplaceable role.
How to use isosafrole to indirectly synthesize piperonyl methyl ketone CAS 28578-16-7?
How to synthesize piperonyl methyl ketone CAS 28578-16-7 from piperonal?
What else is the role of piperonyl methyl ketone CAS 28578-16-7 in the synthesis?
What are the computational chemistry data for piperonyl methyl ketone CAS 28578-16-7?
Indirect Synthesis of Isosafrole
French Gimeno et al. obtained a pale yellow oily piperonyl methyl ketone CAS 28578-16-7 by oxidizing isosafrole with hydrogen peroxide in a formic acid medium, and then dehydrating the glycol with sulfuric acid.
Piperonal is also known as jasmine aldehyde, and its chemical name is 3,4-methylenedioxybenzaldehyde. The synthesis process using piperonal as a raw material has simple raw materials, no large amount of waste gas and waste liquid are discharged during the synthesis process, and is environmentally friendly. The research draws the synthetic route of obtaining piperonyl methyl ketone CAS 28578-16-7 with piperonal as raw material:
In the first step reaction, ammonium acetate is used as a catalyst and glacial acetic acid is used as a solvent to obtain β-nitroisosafrole.
In the second step reaction, reduced iron powder is used as a catalyst. In the reaction process, the amount of hydrochloric acid is different, and the products of the reaction are also different: one is ketoxime, and the other is ketone. Therefore, the amount of hydrochloric acid should be controlled.
Most routes for the synthesis of 3,4-methylenedioxymethamphetamine (MDMA) start from compounds containing a 3,4-methylenedioxyphenyl ring, such as safrole, isosafrole, piperonal, Bromosafrole and piperonyl methyl ketone CAS 28578-16-7 (PMK oil) etc. PMK is currently the most important precursor compound for the synthesis of MDMA in underground processing plants, and MDMA can be prepared by a simple Lukat method or a reductive amination method.
Chemical formula: C10H10O3
Molecular weight: 178.185
CAS Number: 4676-39-5
EINECS Number: 259-630-1
Density: 1.212g/cm3
Boiling point: 275.9℃
Flash point: 111.4℃
Refractive index: 1.547
Hydrophobic parameter calculation reference value (XlogP): none
Number of hydrogen bond donors: 0
Number of hydrogen bond acceptors: 3
Number of rotatable chemical bonds: 2
Number of tautomers: 3
Topological molecular polar surface area: 35.5
Number of heavy atoms: 13
Surface charge: 0
Complexity: 202
Number of isotope atoms: 0
Determine the number of atomic stereocenters: 0
Uncertain number of atomic stereocenters: 0
Determine the number of bond stereocenters: 0
Uncertain number of bond stereocenters: 0
Number of covalent bond units: 1
This is how we see the irreplaceable role of piperonyl methyl ketone CAS 28578-16-7 in our daily lives and chemical production. Mulei (Wuhan) New Material Technology Co. Ltd the pioneer of piperonyl methyl ketone CAS 28578-16-7 producing company in China, knows that every application is special. You can go and get more information about them.
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