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Procaine is a local anesthetic. Procaine causes loss of feeling of skin and mucous membranes. Procaine is used as an injection during surgery and other medical and dental procedures. Owing to the ubiquity of the trade name Novocain, in some regions, Procaine is referred to generically as Novocain. Procaine acts mainly as a sodium channel blocker. Nowadays, Procaine is used therapeutically in some countries due to the functions of Procaine, such as sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects.
l What is the feature of Procaine?
l What is the side effect of Procaine?
l What is the difference between Procaine and Lidocaine?
What is the feature of Procaine?
Procaine is a benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. Procaine has a role as a local anesthetic, a central nervous system depressant, a peripheral nervous system drug and a drug allergen. Procaine is a substituted aniline and a tertiary amino compound, which derives from a 2-diethylaminoethanol and a 4-aminobenzoic acid.
Procaine is a local anesthetic, which means it helps to dull pain in a small area. Procaine is white crystal or crystalline powder, which is easy to dissolve in water. Procaine is less toxic than Cocaine with prolonging the action time. Procaine is a common name that comes to mind when thinking about local anesthetic drugs. In dentistry, Procaine is used to numb an area before getting a filling, crown, or root canal. But Procaine is not as widely used in dentistry anymore. Dentists have turned to other drugs that last longer and have better numbing effects than Procaine. Procaine is also more likely to cause allergic reactions, like swelling or interference with your
What is the side effect of Procaine?
Stop using Procaine and seek emergency medical attention or contact doctor immediately if you experience any of the following rare but serious side effects:
l an allergic reaction, such as difficulty breathing, closing of the throat, swelling of the lips, tongue, or face; or hives;
l chest pain or slow or irregular heartbeats;
l dizziness or drowsiness;
l anxiety or restlessness;
l nausea or vomiting;
l trembling, shaking, or seizures.
Other less serious side effects caused by Procaine, such as numbness, tingling, or minor pain are more likely to occur at or around the injection site. Contact doctor if these effects of Procaine seem excessive or prolonged. If you have any other side effects caused by Procaine occur, please contact to doctor immediately.
Procaine may cause neurotoxicity, which can be divided into excitatory type and inhibitory type. Excitatory type is manifested as nervousness, increased heart rate, shortness of breath, irritability, increased blood pressure, and even convulsions. While manifestations of inhibitory type include drowsiness, loss of consciousness, intermittent breathing, and decreased blood pressure, which eventually lead to cardiac arrest.
Procaine has hypersensitivity and allergic reactions that individual patients may develop methemoglobinemia. If there is too large does of Procaine, fast absorption rate or into blood vessel by mistake can cause toxic reactions.
What is the difference between Procaine and Lidocaine?
Both Lidocaine and Procaine are local anesthetics that anesthetize or numb. Lidocaine is an amide while Procaine is an ester local anesthetic respectively, which refers to their chemical structure and bonding that dictate onset of action, duration of action and metabolism to some degree. Essentially, Procaine and Lidocaine have the same action.
The penetrating power of Procaine and Lidocaine is different. Procaine has weak penetrating power that is generally not used for surface anesthesia. Lidocaine has strong penetrating power that can be used for mucosal surface anesthesia.
The time effect of Procaine and Lidocaine is different. Procaine is a short-acting local anesthetic that the duration of action is 30 minutes. Lidocaine is a moderate local anesthetic that the duration of action is 60 to 90 minutes.
Procaine and Lidocaine have different effects on the body. Procaine is prone to cause allergic reactions so that skin allergy tests are routinely required before application. Lidocaine generally does not cause allergies, and no skin allergy test is required during application.
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