The chemical formula of phenacetin is C10H13NO2, which is a white crystalline solid at room temperature with a melting point of about 134°C. It is a banned drug in many countries.

• What is the dosage of phenacetin?

• What is the drug evaluation for phenacetin?

• What is the production method of phenacetin?

What is the dosage of phenacetin?

1. Compound chlorpheniramine tablets (Puer cold tablets): each tablet contains phenacetin 0.162g, chlorpheniramine 0.002g, aspirin 0.2268g, caffeine 0.0324g, adults take 1-2 tablets/time, 3 times /d . 2. Somedon tablets: each tablet contains 0.15g of aminopyrine, 0.2g of phenacetin, 0.015g of phenobarbital, and 0.05g of caffeine. For headache, toothache, joint pain or dysmenorrhea, etc., orally, 1 tablet at a time if necessary.

What is the drug evaluation for phenacetin?

Antipyretic and analgesic, used to treat fever, headache, neuralgia, etc. Antipyretic effect is stronger than analgesic effect. The potency of the drug is comparable to that of aspirin, the effect is slow and long-lasting, and the toxicity is low. Studies have shown that this product and its metabolite paracetamol have antipyretic effects. Because phenacetin can not be converted into paracetamol with enzyme inhibitors, it can still show obvious antipyretic effect. Therefore, the antipyretic effect after the thread is given is not only produced by its active product, paracetamol. The mild analgesic effect of phenacetin can generally be maintained for 3-4 hours; the synergistic effect of phenacetin in combination with salicylic acids enhances the analgesic effect. Clinically, it is mainly used for antipyretic and analgesic in small animals. This product is also one of the components of APC tablets.

What is the production method of phenacetin?

(1) It is obtained by acetylation of p-aminophenethyl ether. The mixture of benzene, acetic anhydride and p-aminophenethyl ether was heated and azeotroped on an oil bath for 4 hours. After the reaction was completed, the reactant was cooled to precipitate phenatine, which was filtered, washed with cold benzene, and dried. The yield was the theoretical amount. 86%.

(2) Obtained by the action of acetamidophenol and sodium ethoxide: first add p-acetamidophenol to sodium ethoxide, then slowly add iodoethane, heat to reflux for 1h, cool, filter, and the obtained crude product is dissolved in ethanol, Filtration, the filtrate is diluted with hot water, then cooled, filtered and dried to obtain the finished product, and the yield is 80% of the theoretical amount. 

The first method can also use acetic acid instead of benzene as a solvent, and the process is as follows. Heat 40% dilute acetic acid to boiling, put in p-aminophenethyl ether, evaporate the water, add glacial acetic acid when the temperature rises to 150°C, reflux for 1 h, continue to steam, and when the temperature rises above 150°C, take a sample to measure free aminobenzene Diethyl ether, add acetic anhydride according to the amount of residual amino phenethyl ether, reflux reaction for 0.5h, check the end point, reduce pressure after passing the qualification, recover acetic acid until the amino content is below 0.046, and the acid content is below 0.2%, and the reaction liquid is poured into the hot refining mother liquor, Stir to cool down to 40 ℃, filter to obtain crude phenacetin. Refining, adding boiling water or refining mother liquor to the crude phenacetin, heating and stirring to dissolve, filtering, adjusting the filtrate to pH=4.5-4.7 with acid, adding activated carbon and sodium thiosulfate, stirring and decolorizing, filtering, cooling and crystallizing the filtrate, filtration, and air flow Dry, get phenacetin.

Mulei (Wuhan) New Material Technology Co. Ltd has committed to providing the most suitable phenacetin at a reasonable price, and whatever it takes to satisfy the customer’s needs.