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Procaine Hydrochloride is the hydrochloride salt form of procaine. Procaine Hydrochloride is a Benzoic acid derivative with local anesthetic and antiarrhythmic properties, as well as an organic molecular entity. Procaine Hydrochloride is the generic name for the old dental local anesthetic Novocain. Procaine Hydrochloride had a much higher incidence of true allergic reactions than Lidocaine that is most popular today. Procaine Hydrochloride had the advantage of longer action and no need for using Epinephrine with the occasional side effect of speeding up the pulse.
l What is the function of Procaine Hydrochloride?
l What are the side effects of Procaine Hydrochloride?
l What will affect how long Procaine Hydrochloride lasts?
What is the function of Procaine Hydrochloride?
Procaine Hydrochloride is a local anesthetic, which is relatively old. Procaine Hydrochloride is mainly used for local infiltration, some for spinal anesthesia, and some for continuous epidural anesthesia. Researched and developed by anesthesiologists, doctors use Procaine Hydrochloride as an intravenous drip for intravenous general anesthesia, which can not only achieve a sedative effect, but also has a certain analgesic effect. However, because intravenous application is prone to toxic reactions of local anesthetics, Procaine Hydrochloride is not safe enough so that it is slowly replaced by other good intravenous anesthetics.
Procaine Hydrochloride injection is mainly used for infiltration anesthesia, block anesthesia, epidural anesthesia, lumbar spine anesthesia, and occlusive therapy. Oral Procaine Hydrochloride can relieve symptoms such as neurasthenia syndrome, neurasthenia, and autonomic dysfunction.
Procaine Hydrochloride has a good local anesthetic effect, almost no irritation to local tissues. Procaine Hydrochloride is relatively weak penetrating power to the mucous membrane. Except sometimes used for bladder mucosal anesthesia, Procaine Hydrochloride is generally not used for mucosal anesthesia. Procaine Hydrochloride is mainly used for infiltration anesthesia. The tissue is absorbed into the blood or directly instilled slowly from the vein, Procaine Hydrochloride has an inhibitory effect and analgesic effect on the central nervous system, and can reduce the excitability of the myocardium, inhibiting the cardiac conduction tissue, as well as slowing the heart rate.
What are the side effects of Procaine Hydrochloride?
The adverse reactions of Procaine Hydrochloride mainly include neurotoxicity and allergic reactions.
Neurotoxicity is the main side effect of Procaine Hydrochloride, which is divided into excitatory type and inhibitory type. Excitatory type is manifested as nervousness, hyperactivity, and increased heart rate; or even Procaine Hydrochloride can cause shortness of breath, irritability, elevated blood pressure, muscle tremors and convulsions, which eventually cause breathing and heartbeat to stop. Inhibitory type’s manifestations are apathy, lethargy, and loss of consciousness; or even there are shallow breathing, intermittent breathing, slow pulse, and blood pressure, which eventually lead to cardiac arrest.
Procaine Hydrochloride may have hypersensitivity and allergic reactions, while individual patients may develop methemoglobinemia. If Procaine Hydrochloride is given a large dose, fast absorption rate or enters the blood vessel by mistake, Procaine Hydrochloride can cause toxic reactions.
The effects of Procaine Hydrochloride normally do not last very long in the body. In fact, Procaine Hydrochloride is the shortest-acting injectable anesthetic. After Procaine Hydrochloride is injected, you will begin to feel numb after 5 to 10 minutes, while the numbing sensation typically lasts 30 to 60 minutes.
Since Procaine Hydrochloride by itself has a very short duration of action, Procaine Hydrochloride is often used in conjunction with epinephrine to make the effects last a little longer, which last roughly 90 minutes.
What will affect how long Procaine Hydrochloride lasts?
Exactly how long the effects of Procaine Hydrochloride last also depend on the dose administered by doctor or dentist. The dose of Procaine Hydrochloride varies with the type of procedure you are having, the size of the area that needs to be numbed, and the number of nerves that need to be blocked. Your doctor might also give you a higher dose if they wish to numb the area for a longer period of time in order to complete the procedure. The effects of Procaine Hydrochloride also vary slightly from person to person.
In the body, Procaine Hydrochloride is metabolized by an enzyme known as pseudocholinesterase. About 1 in every 5,000 people has a genetic condition that makes them unable to break down Procaine Hydrochloride and similar medications. This condition is called pseudocholinesterase deficiency. People with this deficiency are more sensitive to Procaine Hydrochloride that its effects may last much longer.
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