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2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0 is usually a white powder with a melting point of 189°C. Soluble in water, when the temperature is 20 ℃, the solubility is 2000 g/L. It can exist stably at normal temperature and pressure. It can be prepared by chlorination of 1-dimethylamino-2-propanol, and it is the intermediate of the central inhibitory drug Meisantong and the antihistamine drug phenergan.
What are the characteristics of 2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0?
What is the computational chemical information for 2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0?
How is 2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0 used?
2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0 is incompatible with strong oxidizing agents. Amines are chemical bases. They neutralize acids to form salts and water. These acid-base reactions are exothermic. The heat released per mole of amine in neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides and acid halides. Flammable gaseous hydrogen is produced by combining amines with strong reducing agents such as hydrides. 2-dimethylaminoisopropyl chloride hydrochloride CAS 4584-49-0 can exist stably at normal temperature and pressure, and can be hydrolyzed with an aqueous solution of strong alkali to generate alcohol compounds. When it reacts with an alcoholic solution of a strong base, an elimination reaction occurs to generate an organic compound containing a double bond.
Number of hydrogen bond donors: 1
Number of hydrogen bond acceptors: 1
Number of rotatable chemical bonds: 2
Topological molecular polar surface area: 3.2
Number of heavy atoms: 8
Surface Charge::0
Complexity: 45.3
Number of isotope atoms: 0
Determine the number of atomic stereocenters: 0
Uncertain number of atomic stereocenters: 1
Determine the number of bond stereocenters: 0
Uncertain number of bond stereocenters: 0
Number of covalent bond units: 2
Follow the procedure of Schultz and Sprague with a solution containing 3.77 g. 1-Dimethylamino-2-propanol and 10 ml. 100 ml of chloroform was cooled to a temperature of about 0°C with stirring. The solution was 5.72 g. Freshly distilled thionyl chloride 2 ml. Thereto was added chloroform. The reaction mixture was allowed to reach ambient temperature in about 30 minutes and then heated to reflux temperature for an additional 30 minutes. The precipitated material redissolves on heating. 1-Dimethylamino-2-chloropropane hydrochloride begins to crystallize from the boiling solvent. The reaction mixture was cooled, diluted with ether and filtered. The reaction product containing 1-dimethylamino-2-chloropropane hydrochloride weighed about 5.5 g. (95% yield). Recrystallization obtains purified 1-dimethylamino-2-chloropropane hydrochloride with a melting point of 192°-194°C.
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