Views: 60 Author: Site Editor Publish Time: 2022-07-01 Origin: Site
Tadalafil, a selective and reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5). When sexual stimulation results in the local release of nitric oxide, PDE5 is inhibited by Tadalafil, increasing cGMP levels in the corpus cavernosum, which causes smooth muscle relaxation and blood flow into penile tissue, resulting in an erection, as in asexual stimulation.
l How is Tadalafil used?
l What is the difference between Sildenafil and Tadalafil?
l What are the precautions for using Tadalafil?
Tadalafil does not contain hormones and has no dependence, and it is precisely the drug of choice for the treatment of poor erection hardness. It is used in two ways, a small dose taken daily and a slightly larger dose taken as needed.
If it is taken in small doses every day, 5 mg can be used, and it can be taken normally regardless of whether there is sex, which can play a better therapeutic role; if it is taken on demand, 10-20 mg can be used, and it only needs to be taken before sex, but If you take it as needed, I also recommend that you use 5 mg first, and then adjust the dose according to the effect.
The main differences between the two are as follows:
1. The stable effect of Tadalafil lasts for 36 hours, and sildenafil only lasts for 4 hours.
2. Tadalafil is used to take effect quickly, and there is no need to deliberately plan medication time and sexual life, while sildenafil is generally taken 30-60 minutes before sexual life; Tadalafil is compared with sildenafil, choosing sex time is more free, more natural and more leisurely.
3. Tadalafil is easy to take, and its efficacy is not affected by high-fat diet and moderate alcohol consumption. After taking sildenafil, moderate alcohol consumption can speed up vasodilation, which can lead to a rapid heart rate, lower blood pressure, severely overload the heart, and increase the heart rate. If the heart is poorly tolerated, arrhythmias or other accidents can easily occur, and can even be life-threatening.
Therefore, sildenafil is best taken on an empty stomach or 2 hours after a meal, as food may affect the absorption and action of the drug. If it is taken after eating a high-fat food, it will take a long time to be effective.
4. The incidence of adverse reactions of Tadalafil is lower than that of sildenafil;
Clinical studies have shown that Tadalafil can enhance the antihypertensive effect of nitrates. This is thought to be the result of the combined action of nitrates and Tadalafil on the nitric oxide/cGMP pathway. Therefore, it is contraindicated in patients taking any form of nitrates.
Sexual activity poses potential heart risks to people with heart disease. Therefore, medications for erectile dysfunction, including Tadalafil, should not be used in patients with heart disease who are advised against sexual intercourse. For patients with pre-existing heart disease, physicians should consider the potential cardiac risks of sex. The following clinical trials have not included patients with the following cardiovascular diseases, therefore Tadalafil is strictly contraindicated in these groups.
Mulei (Wuhan) New Material Technology Co. Ltd has undertaken to increase the need of Tadalafil and to make them more effective, reliable and consistent.
Our company was founded in 2016 since then we have pioneered in the manufacturing and trading of organic intermediates, pharmaceutical intermediates, chemical solvents and agrochemical. For us, product quality and customer service are of the most importance. read more