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2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2 is used as a solvent for cellulose acetate, an intermediate for organic synthesis, a metal complexing agent, a paint drying agent, a lubricant, and an insecticide.
What are the synthetic routes for 2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2?
How to synthesize 4-phenbutan-2-ol by ethyl acetoacetate method using benzyl chloride and ethanol as raw materials?
What are the characteristics of 2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2?
What are the relevant parameters of 2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2?
1. Synthesis of 2-bromo-1-isopropoxy-4-nitrobenzene via 3-bromo-4-fluoronitrobenzene and isopropanol
2. Synthesize 2-bromo-1-isopropoxy-4-nitrobenzene by 2-iodopropane and 2-bromo-4-nitrophenol with a yield of about 70%.
1) Ethanol is oxidized to obtain acetic acid;
2) Acetic acid and ethanol generate ethyl acetate;
3) ethyl acetate is reacted with sodium ethoxide to obtain ethyl acetoacetate;
4) Reaction of active methylene with benzyl chloride to obtain benzyl substituent;
5) After the basic hydrolysis of the ester, the corresponding carboxylic acid is obtained by acidification;
6) Decarboxylation by heating;
7) Reduction of ketones to alcohols.
2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2 is a colorless or slightly yellow liquid with an ester odor. Soluble in most organic solvents, and a small amount in hot water. The pure liquid of this reagent exists mainly in the enol form, but in the aqueous solution it mainly exists in the ketone form.
The special property is that it has enol interconversion, one carbonyl becomes enol, and forms a hydrogen bond with another carbonyl, thus forming a six-membered ring with a conjugated structure, which is very stable, so it exists in enol. And has the properties of olefins.
There is a strong electron-donating hydroxyl group on the carbon-carbon double bond of the enol isomer, so it can be attacked by the bromine cation generated by the bromine element, and the substitution reaction occurs, and finally 3-bromo-2,4-pentanedione is obtained.
2-Pentanone also has a certain equilibrium concentration of the enol isomer, but the amount is very low, so the reaction with bromine is very slow. The reaction requires acid catalysis and the main product is 3-bromo-2-pentanone. It is also possible to use base catalysis, but base catalysis will cause multiple brominations, and finally a haloform reaction occurs.
Density 1.3±0.1 g/cm3
Boiling Point 282.3±13.0 °C at 760 mmHg
Molecular Formula C11H13BrO
Molecular Weight 241.124
Flash Point 42.5±7.2 °C
Exact Mass 240.014969
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.541
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