What are the properties, uses, and precautions of Procaine Hydrochloride?

Procaine Hydrochloride is a pharmaceutical product. Procaine Hydrochloride acts on peripheral nerves to produce conduction blocking effects, relying on concentration gradients to penetrate the nerve cell membrane diffusely, blocking sodium channels medially, causing an increase in the excitation threshold of the nerve cell, loss of excitability and conductivity, and blocking of information transmission, with good local anesthetic effects. The next section describes the physical and chemical properties and effects of Procaine Hydrochloride and includes some precautions.

Here is the content list:

l Physical and chemical properties

l Action

l Precautions

Physical and chemical properties

Appearance is white crystalline or crystalline powder, odorless, slightly bitter taste, followed by a feeling of paralysis. Procaine Hydrochloride has a melting point of 155-156 °C, a boiling point of 195-196 °C/17 mm, and a flashpoint of 195-196 °C/17 mm. Procaine Hydrochloride is soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, and insoluble in ether. The ester bond of Procaine Hydrochloride is readily hydrolyzable and temperature and pH affect the rate of hydrolysis. The aromatic amine group is easily oxidized and discolored. When preparing injections, the pH should be adjusted to 3.5-5.0, and the sterilization temperature and time should be controlled. 30 min is suitable for sterilization by flowing steam at 100°C. Amperometric inert gas, antioxidant, metal ion removal, or metal ion masking agent should be added. Aromatic carbamates can undergo a diazotization-coupling reaction, i.e., after reaction with sodium nitrite in dilute hydrochloric acid, the addition of alkaline β-naphthol test solution 5 produces an orange (scarlet) azoic compound precipitate.

Action

Procaine Hydrochloride can certainly reduce pain during surgery. Procaine Hydrochloride Injection is an FDA-approved product for prescription use as a local anesthetic. The decline in memory and thinking ability usually occurs with age. Early studies have shown that Procaine Hydrochloride is given orally or by injection does not improve most memory and thinking skills in older people. In addition, it can lead to side effects: diseases that interfere with thinking, such as Alzheimer's disease (dementia). Early studies have shown that Procaine Hydrochloride does not improve the thinking ability of people with dementia. But the effects of the latter points are yet to be proven.

Precautions

It is important to note that if you are pregnant, it is not safe to self-administer Procaine Hydrochloride. If you are breastfeeding, it is best to avoid using Procaine Hydrochloride. Secondly, if you have myasthenia gravis, you should not give Procaine Hydrochloride intravenously. Pseudocholinesterase deficiency, a genetic disorder. People with this disorder are sensitive to certain anesthetic drugs. If you have this disorder, you should not have Procaine Hydrochloride injected. Procaine Hydrochloride may make SLE worse. Do not use Procaine Hydrochloride if you have SLE.

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