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How to understand 2-Bromo-1-phenyl-1-pentanone?

Views: 0     Author: Site Editor     Publish Time: 2021-08-06      Origin: Site

2-Bromo-1-phenyl-1-pentanone is an organic intermediate, which can be obtained from pentanone as raw material and brominated by sodium bromide. It has been reported in the literature that it can be used to prepare histone demethylase inhibitors. Its CAS number is 4509-91-5, molecular weight is 241.12400, the molecular formula is C11H13BrO, Below we will introduce 2-Bromo-1-phenyl-1-pentanone from several aspects such as the preparation.


Here is the content list:

l How should 2-Bromo-1-phenyl-1-pentanone be prepared?

l What are the applications of 2-Bromo-1-phenyl-1-pentanone?

l What are the applications of 2-Bromo-1-phenyl-1-pentanone?


How should 2-Bromo-1-phenyl-1-pentanone be prepared?

At room temperature, add 16.2g (0.1mol) of pentanone and 30.9g (0.3mol) of sodium bromide into a 500mL round-bottomed flask. After stirring evenly, add 24g (0.2mol) of 30% hydrochloric acid and drip slowly. Add 19g (0.15mol) 30% hydrogen peroxide. After the dropping, continue the reaction for 1~2h. After the reaction is monitored by TLC, stop stirring, stand still for layering, wash with saturated sodium carbonate and saturated brine, and combine the organic phases. After concentration, it is dried over anhydrous magnesium sulfate to obtain 2-Bromo-1-phenyl-1-pentanone, a bright yellow oily liquid, with a yield of 95% and a purity of 98% (HPLC method).


What are the applications of 2-Bromo-1-phenyl-1-pentanone?

2-Bromo-1-phenyl-1-pentanone can be used to prepare substituted imidazole derivatives with the following structure, which have high-efficiency KDM1A enzyme inhibitory activity and selectivity over monoamine oxidase (MAO), and can be used for the prevention or treatment of diseases and disorders related to histone demethylase activity.


What are the peripheral products of 2-Bromo-1-phenyl-1-pentanone?

The upstream products of 2-Bromo-1-phenyl-1-pentanone are benzaldehyde, and the downstream products are 2-(methylamino)-1-pentanone-1-one, hydrochloride, 1-pentanone-1,2-dione, 4'-FLUOROVALEROPHENONE, etc. 4'-FLUOROVALEROPHENONE is a colorless, adhesive crystalline solid with a molecular formula of C11H13FO and a melting point of 23-25 degrees. The storage conditions should be kept in a sealed container and stored in a cool and dry place to ensure a good working room. In the ventilation or exhaust device, if used and stored by following the specifications, it will not decompose, and there is no known dangerous reaction. Oxidation should be avoided during use. 2-Bromo-1-phenyl-1-pentanone can be seen from the formula composition and manufacturing process that the components of the seal are complex and diverse, and the quality control items of the seal are only common items for the conventional formula process, and cannot be used for all The factors that may affect the quality and safety of drugs are controlled. The manufacturer of 2-Bromo-1-phenyl-1-pentanone must establish a good and close relationship with the manufacturer of the seal, and understand the items in the proposed seal that may be introduced into the drug that needs to be researched and controlled, and establish Targeted internal control quality standards for seals.


Nowadays, 2-Bromo-1-phenyl-1-pentanone has been well developed and has been widely used in chemicals. Mulei (Wuhan) New Material Technology Co. Ltd. conducted a lot of tests on 2-Bromo-1-phenyl-1-pentanone before leaving the factory to determine the quality of the product. If you need 2-Bromo-1-phenyl-1-pentanone business, you can consider using our cost-effective products.

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