Views: 0 Author: Site Editor Publish Time: 2022-11-08 Origin: Site
In the current synthesis process of piperonyl methyl ketone PMK CAS 28578-16-7, most of them have to go through several steps to obtain the product, and the yield of the obtained piperonyl methyl ketone PMK powder CAS 28578-16-7 is still not ideal. Therefore, how to reduce the steps required for the reaction and select Appropriate catalysts, solvents, and oxidants to improve the yield of the product deserve further research.
What is the role of piperonyl methyl ketone PMK oil CAS 28578-16-7?
How to use isosafrole to synthesize piperonyl methyl ketone CAS 28578-16-7?
What is the synthesis process of Potassium piperonyl methyl ketone CAS 28578-16-7 Schiff Base?
piperonyl methyl ketone CAS 28578-16-7 is a very important pharmaceutical intermediate. piperonyl methyl ketone CAS 28578-16-7 can be used for the synthesis of α-methyldopa, a drug used in the treatment of hypertension, as well as for MDA (3,4-methylenephenylisopropylamine) and MDMA (3,4-methylenedioxy Synthesis of drugs such as phenyl-N-methylisopropylamine). piperonyl methyl ketone CAS 28578-16-7 can also be used as a fragrance for the preparation of fruity, fresh floral fragrances, and for perfumery in soaps, detergents, cosmetics and perfumes.
Synthesis of Isosafrole as Raw Material
Isosafrole is an isomer of safrole. Using isosafrole as raw material, in an organic acid medium, isosafrole is oxidized to piperonyl methyl ketone CAS 28578-16-7. According to the required steps of the reaction, it can also be divided into direct synthesis method and indirect synthesis method.
The reaction process of directly oxidizing isosafrole to piperonyl methyl ketone CAS 28578-16-7 with peroxycarboxylic acid using isosafrole as raw material in organic acid medium was discussed. The "one-step" process does not require sulfuric acid treatment, uses less acid, is simple to operate, is safe, and has little environmental pollution. In the presence of organic acids, hydrogen peroxide first reacts with it to generate peroxyacids, and then oxidizes olefins in the system to generate epoxy compounds. Due to the presence of formic acid in the system, the epoxy compound reacts with formic acid to form a trans-diol monoformate, which is hydrolyzed to obtain a trans-diol, and the trans-diol is heated under acidic conditions and is isomerized by an enol intermediate into Ketones.
Synthesis of Potassium piperonyl methyl ketone CAS 28578-16-7 Schiff Base. Dissolve 10 mmol glycine and equimolar potassium hydroxide in an appropriate amount of absolute ethanol, stir at room temperature until most of the glycine is dissolved, and filter with suction. The filtrate is a colorless and transparent potassium glycinate ethanol solution. Take 10 mmol of piperonyl methyl ketone CAS 28578-16-7 in a round-bottomed flask filled with an appropriate amount of anhydrous ethanol, and stir to dissolve at room temperature. Then, the potassium glycinate ethanol solution was dropped into a water bath at 50-60°C and stirred for 3 h, left to stand, cooled overnight, filtered with suction, washed with absolute ethanol, and dried in vacuo to obtain a pale yellow solid.
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