How much do you know about Pregabalin?

The chemical name of Pregabalin is (S)-3-aminomethyl-5-methylhexanoic acid, the molecular formula is C8H17NO2, is an anti-epileptic drug, mainly used to treat postherpetic neuralgia clinically.

• What is the mode of action of pregabalin?

• What is Pregabalin used for?

• What other drugs interact with pregabalin?

• What are warnings and precautions for pregabalin?

What is the mode of action of pregabalin?

Pregabalin can be mainly used to treat neuralgia and fibromyalgia after herpes zoster. Pregabalin is an aminobutyric acid analogue. Its structure and function are similar to gabapentin. It has the effects of anti epilepsy, analgesia and anti anxiety. If patients take Pregabalin capsule, they may have dizziness, drowsiness, headache, language disorder, forgetfulness and other adverse reactions, and may also cause weight gain, but the probability of occurrence is relatively low. If necessary, you can go to the dermatology department of the hospital for examination and treatment.

Pregabalin capsules are classified as a controlled use product. Delay in approval of Pregabalin capsules and classification as a controlled product, thus emphasizing that Pregabalin capsules are the first FDA-approved drug for the treatment of diabetic peripheral neuropathy and postherpetic neuralgia. Meanwhile, Pregabalin capsules have analgesic, anticonvulsant and anxiety-relieving effects.

What is Pregabalin used for?

Pregabalin is a gamma-aminobutyric acid (GABA) analog, similar in structure and action to gabapentin, and has antiepileptic, analgesic and anxiolytic activities. The mechanism of antiepileptic action of Pregabalin is unclear. In laboratory studies, Pregabalin has anticonvulsant activity in various epilepsy models; the activity spectrum in animal models is similar to that of gabapentin, but Pregabalin is 3 to 10 times more active than gabapentin.

After oral administration of Pregabalin, it takes effect within 30 minutes for acute toothache and lasts for about 5 hours, and it takes effect in 1 week for diabetic neuropathy. The peak time is about 1h, and the bioavailability is 90%. It is less metabolized in the liver, 92% to 99% is excreted in the original form through the kidneys, less than 0.1% of the oral dose is excreted in the feces, and the half-life is 5 to 6.5h.

What other drugs interact with pregabalin?

1. The combined use of thiazolidinedione antidiabetic drugs increases the risk of weight gain and peripheral edema, and should be used with caution.

2. Pregabalin can enhance the sedative effect of central nervous system depressants.

3. Pregabalin enhances the sedative effects of alcohol.

4. Food can reduce the bioavailability of Pregabalin.

What are warnings and precautions for pregabalin?

1. Patients with congestive heart failure.

2. Patients with ophthalmic diseases.

3. Diabetic patients.

4. Effects of the drug on children: The safety and efficacy of the drug have not been established.

5. The effect of drugs on pregnancy: not yet clear.

6. The effect of the drug on breastfeeding: Not yet clear.

7. It should be checked or monitored before and after taking Pregabalin and during medication: regular blood biochemical tests.

Mulei (Wuhan) New Material Technology Co. Ltd has focused on the development and production of Pregabalins for several years. And it commits to provide perfect service for every customer from all over the world.