How does antiparasitic drug Levamisole work?

Levamisole is an anthelmintic drug. Levamisole is co-administered with fluorouracil in the treatment of Dukes' stage C colon cancer. Levamisole restores immune function through stimulating antibody formation, enhancing T-cell activity, and potentiating macrophage function. Levamisole is an anthelmintic agent used principally for the treatment and control of a range of nematodes in domestic species and as a microfilaricide in dogs.

How does antiparasitic drug Levamisole work?

How to use Levamisole?

What can Levamisole be used for?

How does antiparasitic drug Levamisole work?

Levamisole stimulates the body's immune system to help treat and protect against illness. Levamisole is used in combination with other medications in the treatment of colon cancer.

Levamisole is used with another cancer medicine to help make it work better against cancer of the colon. Levamisole is available only with your doctor's prescription.

Levamisole can stimulate formation of antibodies to various antigens, enhance T-cell responses by stimulating T-cell activation and proliferation, potentiate monocyte and macrophage functions including phagocytosis and chemotaxis, and increase neutrophil mobility, adherence, and chemotaxis. Besides its immunomodulatory function, Levamisole has other pharmacologic activities, including inhibition of alkaline phosphatase and cholinergic activity.

Levamisole is an anthelmintic drug that possesses nonspecific immunostimulatory properties. In deficient animals and humans, Levamisole restores many different immunologic functions, suggesting that Levamisole acts on multiple populations of cells, including neutrophils, macrophages, and T cells. The effects of Levamisole on the immune response and its pharmacologic activity indicate that Levamisole is a thymomimetic agent.

How to use Levamisole?

Take Levamisole exactly as prescribed. Do not increase your dose or take Levamisole more often. Your condition will not improve faster by taking more Levamisole, but side effects will be increased. Levamisole may be taken with food or milk to minimize nausea.

The exact amount of Levamisole you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition. If you vomit shortly after taking a dose of Levamisole, check with your doctor. You will be told whether to take Levamisole again or to wait until the next scheduled dose.

The dose of Levamisole will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Levamisole. If your dose is different, do not change it unless your doctor tells you to do so. The amount of Levamisole that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take Levamisole depend on the medical problem for which you are using Levamisole. If you miss a dose of Levamisole, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Call your doctor or pharmacist for instructions.

What can Levamisole be used for?

Levamisole is an antihelminthic drug that is commonly used for the treatment of parasitic, viral, and bacterial infections. Levamisole is used to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers, generally being used as the monohydrochloride salt. Levamisole is also widely used as an adulterant to Cocaine. Levamisole has a role as an antinematodal drug, an antirheumatic drug, an immunomodulator, an immunological adjuvant and an EC 3.1.3.1.

Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. Levamisole was manufactured by Janssen and first used in 1969 as an agent to treat worm infestations. Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this, Levamisole was used as an antirheumatic therapy in the 1970s and 1980s for patients with rheumatoid arthritis. Because of its immunomodulatory effects, Levamisole has been studied in the treatment of various immune-mediated diseases, with some studies showing positive results. Levamisole has also been used in combination with other drugs for the treatment of various cancers. Levamisole was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis. Interestingly, Levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.

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