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Procaine is a local anesthetic. Procaine is white crystal or crystalline powder, which is easy to dissolve in water. Procaine is less toxic than Cocaine with prolonging the action time. Except for the central nervous system and cardiovascular system reactions caused by overdose, allergic reactions of Procaine are occasionally reported.
l How does Procaine work?
l What should be paid attention to when using Procaine?
l How to deal with the condition that Procaine is used incorrectly?
How does Procaine work?
Procaine works as an anesthetic when injected. However, Procaine doesn't get absorbed well when it is taken by mouth. It is unclear how it might work for medicinal uses when taken by mouth.
Procaine is generally lipid-soluble tertiary amine compounds that inhibit propagated action potentials by blocking Na⁺ channels. Procaine can stabilize the cell membrane and reduce its permeability to ions. When the nerve impulse reaches, sodium and potassium ions cannot enter and exit the cell membrane to produce depolarization and action potentials, thereby producing local anesthesia. Procaine has poor penetrating power to the mucous membrane and is not suitable for surface anesthesia. Procaine has low toxicity. Procaine can be used for infiltration anesthesia, block anesthesia and epidural anesthesia.
Procaine takes effect after the injection and can be maintained for 30 to 45min. After adding epinephrine, the maintenance time of Procaine can be extended by 20%. Procaine can be hydrolyzed by esterase in plasma and converted into para-aminobenzoic acid and diethylaminoethanol. The former can resist the antibacterial effect of sulfa drugs so that it should be avoided to use Procaine with sulfa drugs at the same time.
What should be paid attention to when using Procaine?
Procaine is administered as an injection in a hospital or clinic setting. Missing a dose of Procaine will not happen. Skin allergy test should be done before medication as I the allergic reaction Procaine has.
Before using Procaine, talk to doctors if you have liver problems, heart problems, bleeding or blood clotting problems, a neuromuscular disease such as myasthenia gravis, or other serious medical conditions.
You may not be able to use Procaine, or you may require a dosage adjustment of Procaine or special monitoring during treatment.
It is not known whether Procaine will be harmful to an unborn baby. Do not use Procaine without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Procaine passes into breast milk. Do not use Procaine without first talking to your doctor if you are breast-feeding a baby.
Since there will be decreased sensation of the area where Procaine is injected, use caution to avoid injury to the area during and following treatment.
How to deal with the condition that Procaine is used incorrectly?
If inhaling Procaine incautiously, move the victim to fresh air to keep breathing. Seek medical attention if feeling unwell.
If Procaine contact with skin, take off all contaminated clothing immediately and take a shower immediately.
If Procaine contact with eyes, wash carefully with water for several minutes.
If ingesting Procaine incautiously, immediately rinse mouth with plenty water and call a physician.
The emergency rescuers should wear personal protective equipment to against Procaine, such as rubber gloves and air-tight goggles. Stay away from Procaine leaks to stay upwind. The Procaine leakage area should be enclosed with safety belts to control the entry of non-related personnel. Prevent Procaine entry into the sewer. Sweep and collect dust of Procaine to seal it in a closed container.
Procaine should be handled in a well-ventilated place, as well as preventing Procaine from spreading. Wear suitable protective equipment and wash hands thoroughly after handling.
If dust or aerosols of Procaine are generated, use local exhaust. Keep Procaine into the container tightly closed, storing in a cool and dark place. Procaine should be stored away from incompatible materials such as oxidizers.
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